Asymmetric synthesis and absolute stereo
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Jack Deeter; Jeff Frazier; Gilbert Staten; Mike Staszak; Leland Weigel
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Article
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1990
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Elsevier Science
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French
โ 331 KB
Reduction of 3-(dialkylamino)-1-aryl-t-propanones with a 2:l complex of [(2R,3S-(+)-4--dimethylamino-1,2-diphenyl-3-methyl-2-butanol] (8) and lithium aluminum hydride (LAH) provided the corresponding 1,Saminoalcohols in high ee's (SO-88%). This process was developed and applied to the synthesis of L