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Asymmetric synthesis of ACE inhibitor-Benazepril HCl via a bioreductive reaction

✍ Scribed by Ching-Yao Chang; Teng-Kuei Yang

Book ID: 104359952
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 207 KB
Volume: 14
Category: Article
ISSN: 0957-4166
DOI: 10.1016/s0957-4166(03)00453-1

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✦ Synopsis

An enantioselective synthesis of the potent angiotensin converting enzyme (ACE) inhibitor (2S, 3%S)-2-(1-carboxymethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-4-phenylbutyric acid ethyl ester hydrochloride, Benazepril HCl 4, has been achieved through an asymmetric reduction of 4-(2-nitrophenyl)-2,4-dioxobutyric acid ethyl ester 6b employing baker's yeast as the reductive catalyst.

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