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Total synthesis of (−)-diospongin A and (+)-cryptofolione via asymmetric aldol reaction

✍ Scribed by Rayala Naveen Kumar; H.M. Meshram


Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
422 KB
Volume
52
Category
Article
ISSN
0040-4039

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✦ Synopsis


Diastereoselective reduction Ring


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First Total Synthesis of (-)-Diospongin
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A Concise Total Synthesis of Diospongins
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## Abstract The total synthesis of the diarylheptanoids (−)‐diospongin A (**1**) and B (**2**) was achieved stereoselectively __via__ the __δ__‐lactone intermediate **6**. The key reactions involved are a stereoselective reduction of __β__‐keto ester and the __Horner–Wadsworth–Emmons__ and intramol