## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
Asymmetric Synthesis of a C-3 Substituted Pipecolic Acid
β Scribed by Souers, Andrew J.; Ellman, Jonathan A.
- Book ID
- 121490256
- Publisher
- American Chemical Society
- Year
- 2000
- Tongue
- English
- Weight
- 47 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
The Michael addition of R2CuLi or R2CuMgBr to 4-phenyl-3,4,7,8-tetrahydro-6H-pyrido (2, l-c)(1,4)oxazin-1-one 2, readily obtained from 2-cyano-6-phenyloxazolopiperidine 1, led to the formation of alkylated lactones 4a-d in high yield and with complete diastereoselectivity. Transformation of lactones
Three protected 3-substituted pipecolic acid analogs were prepared as constrained chimeric amino acid building blocks. The concise synthetic route enables the synthesis of other derivatives with sidechaln functionality of amino acids as well.