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Asymmetric synthesis of 3,3-diphenyl-2-methylalanine, a new unusual α-amino acid for peptides of biological interest

✍ Scribed by Carlos Cativiela; María D. Díaz-de-Villegas; José A. Gálvez

Book ID
104203359
Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
688 KB
Volume
50
Category
Article
ISSN
0040-4020

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✦ Synopsis

Abstrect: A strategy of highly stereoselective enolate trapping of lithium (IS,ZR,4R)-lOdicyclohexylsulfamoylisobornyl-2-cyano-3,3-diphenylpropanoate combined with the appropriate rearrangement process allows the asymmetric synthesis of a novel a-methyl amino acid derived from 3,3diienylalanine (Dip).

📜 SIMILAR VOLUMES

Chiral cynthesis of D- and L-3,3-dipheny
Chiral cynthesis of D- and L-3,3-diphenylalanine (DIP), unusual α-amino acids for peptides of biological interest
✍ Huai G. Chen; V.G. Beylin; M. Marlatt; B. Leja; O.P. Goel 📂 Article 📅 1992 🏛 Elsevier Science 🌐 French ⚖ 253 KB

The asymmetric syntheses of D-(R)-(-)-and L-(S)-(+)-3,3diphenylahmine (Dip) are described Currently, there is great interest in the design and synthesis of unusual a-amino acids which may provide specific conformational restraint, and also biostability to degradation by peptidases to small peptides