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Asymmetric synthesis of (2S,4S)-2,4-diaminoglutaric and (2S,3S)-2,3-diamino-2, 3-dimethylsuccinic acids using chiral Ni(II) complexes

✍ Scribed by Yu. N. Belokon'; N. I. Chernoglazova; A. S. Batsanov; N. S. Garbalinskaya; V. I. Bakhmutov; Yu. T. Struchkov; V. M. Belikov


Book ID
112449417
Publisher
Springer
Year
1987
Tongue
English
Weight
510 KB
Volume
36
Category
Article
ISSN
1573-9171

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The synthesis of 3-prolinomethionine can be easily achieved in a diastereoselective and enantioselective way via zinc-enolate cyclisation. After transmetallation by CuCN.2LiCI, the zinc--copper derivative was reacted with S-methyl methanesulfonothioate leading in a "one-pot" procedure, to N-(0t-meth