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Asymmetric synthesis of 1-aryl 2,3,4,5-tetrahydro-2-benz[c]azepines

✍ Scribed by Rocı́o Gámez-Montaño; Marı́a Isabel Chávez; Georges Roussi; Raymundo Cruz-Almanza


Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
109 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis


The first stereoselective synthesis of 1-aryl-2-benz[c]azepines is described using oxazolidines as chiral inducers.


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Practical stereoselective synthesis of (
✍ Tomoichi Shinohara; Kazumi Kondo; Hidenori Ogawa; Toyoki Mori; Kyoko Nozaki; Tam 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 134 KB 👁 1 views

Highly enantioselective asymmetric hydrogenation of readily accessible olefins, (E)- and (Z)-[1-(toluene-4-sulfonyl)-1,2,3, 4-tetrahydro-1H-benzo[b]azepin-5-ylidene]acetic acid (4a and 4b, respectively) and [1-(toluene-4-sulfonyl)-2, 3-dihydro-1H-benzo[b]azepin-5-yl]acetic acid (4c), is presented as