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Asymmetric synthesis: Modification of chiral ferrocenylamine ligands for the gold(I)-catalyzed aldol reaction

✍ Scribed by Stephen D. Pastor*; Antonio Togni

Book ID: 104226672
Publisher: Elsevier Science
Year: 1990
Tongue: French
Weight: 143 KB
Volume: 31
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)94641-0

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✦ Synopsis

The synthesis of a chiral ferrocenylamine ligand, (R)-(s)-11, with a modifiable ester group is described. High diastereo-and enantioselectivity were obtained in the gold(I)-catalyzed aldol reaction using (R)-(S)-11 as a ligand. The formation of a single enantiomer of a targeted chiral compound is today a topic of fundamental importance. Particularly challenging is the development of methodology for enantioselective C-C bond formation with a chiral transition-metal catalyst.' PhCHO + CNCH2COpCH3 A~(cyclo-cgH~~NC)~~~ (3

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