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2D-NMR ConformationaL Studies of ChiraL Functionalized Ferrocenylphosphine Ligands for the Gold(I)-Catalyzed Aldol Reaction

โœ Scribed by Antonio Togni; Ruth K. Blumer; Paul S. Pregosin

Book ID
102859375
Publisher
John Wiley and Sons
Year
1991
Tongue
German
Weight
542 KB
Volume
74
Category
Article
ISSN
0018-019X

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โœฆ Synopsis

The conformations in solution of six selected chiral 1,l'-bis(dipheny1phosphino)ferrocenyl ligands bearing functionalized side chains, the diastereoisomers 4 and 5 and 6 9 , have been elucidated by 2D-NMR methods (COSY, TOCSY, NOESY, and 1H,31P and 'H,I3C correlations). The possible relationship between the preferred conformation and the stereoselectivity observed in the gold(1)-catalyzed asymmetric aldol condensation in the presence of these ligands is discussed.

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