Asymmetric synthesis IV. Preparation of chiral α-aminonitriles from a new N-cyanomethyl-1,3-oxazolidine synthon

✍ Scribed by José L. Marco; Jacques Royer; Henri-Philippe Husson

• Publisher: Elsevier Science
• Year: 1985
• Tongue: French
• Weight: 216 KB
• Volume: 26
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)89192-3

✦ Synopsis

The synthesis of (-I-N-cyanomethyl-&phenyl-1,3-oxazolidine 1 is reported. Good yiglds and moderate diastereomeric excesses (d.e.s. I of mono-and di-substituted a-aminonitriles

were obtained from this simple chiral template.