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Asymmetric synthesis and absolute stereochemistry of 4,4-bis-(trifluoromethyl)imidazoline based ACAT inhibitors

✍ Scribed by Hui-Yin Li; Indawati DeLucca; Spencer Drummond; George A. Boswell

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 639 KB
Volume: 53
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(97)00081-1

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✦ Synopsis

An asymmetric synthesis of 1, a potent orally active ACAT inhibitor, is reported.

The absolute configuration of 1 has been determined by exciton CD spectra and X-ray crystal structure analysis.

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