𝔖 Bobbio Scriptorium
✦   LIBER   ✦

ChemInform Abstract: Singlet Oxygen Oxidation of Pyrroles: Synthesis and Chemical Transformations of Novel 4,4-Bis(trifluoromethyl)imidazoline Analogues.

✍ Scribed by H.-Y. LI; S. DRUMMOND; I. DELUCCA; G. A. BOSWELL

Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
28
Category
Article
ISSN
0931-7597

No coin nor oath required. For personal study only.

✦ Synopsis

Singlet Oxygen Oxidation of Pyrroles: Synthesis and Chemical Transformations of Novel 4,4-Bis(trifluoromethyl)imidazoline Analogues.

-A new method to prepare 4,4-bis(trifluoromethyl)imidazolines is described via facile photooxidative cleavage of the pyrrole (I) with singlet oxygen. In addition, it is shown that MCPBA-mediated oxidation of the pyrrole (I) also gives 4,4-bis(trifluoromethyl)imidazole, but in low yields. The imidazoles (IV) and (VI) show good activity as ACAT inhibitors and cholesterol biosynthesis inhibitors.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Reactions of Polyfl
ChemInform Abstract: Reactions of Polyfluorinated Thietanes Selective Synthesis of 4-R-2,2-Bis(trifluoromethyl)thietane-1-S-oxides and 2-Substituted 5-Fluoro-4-(trifluoromethyl)-2,3-dihydrothiophenes.
✍ Viacheslav A. Petrov; William J. Marshall πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 33 KB πŸ‘ 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v

ChemInform Abstract: A Novel Class of Co
ChemInform Abstract: A Novel Class of Compounds: Synthesis of 5,5β€²-Carbonyl-bis(5,6-dihydro-4H-furo- and Thieno-[2,3-c]pyrrol-4-ones).
✍ Gani Koza; Metin Balci πŸ“‚ Article πŸ“… 2012 πŸ› John Wiley and Sons βš– 16 KB

## Abstract Key steps of the synthesis are the regioselective hydrolysis of biscarboxylate (III), the monoacyl azide formation and subsequent Curtius rearrangement to give isocyanate (VI), and the sequential ring closure to give carbonylbis(dihydrothienopyrrole) (X) (and the carbonylbis(dihydrofuro

ChemInform Abstract: Ring-Chain Transfor
ChemInform Abstract: Ring-Chain Transformation in the 4-Hydroxy-3,4-dihydro-1,2,4-triazine Series and a Novel Method for the Synthesis of 1,2,4-Triazine-4-oxides.
✍ D. N. KOZHEVNIKOV; V. N. KOZHEVNIKOV; V. L. RUSINOV; O. N. CHUPAKHIN; E. O. SIDO πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 36 KB πŸ‘ 1 views

Ring-Chain Transformation in the 4-Hydroxy-3,4-dihydro-1,2,4triazine Series and a Novel Method for the Synthesis of 1,2,4-Triazine-4-oxides. -Condensation of the hydrazones (I) with aldehydes or ketones (II) affords a tautomeric mixture (III)/(IV) of triazines. The ringchain transformation of these