## Abstract An efficient and reliable multiโstep synthesis of 251 natural productโlike [5.5]โspiroketals on solid supports has been developed. As central key step, a double intramolecular heteroโMichael (DIHMA) reaction to alkynones was applied. The sequence allows for introduction of numerous subs
Asymmetric Solid-Phase Synthesis of 6,6-Spiroketals
โ Scribed by Okram Barun; Stefan Sommer; Herbert Waldmann
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 171 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0044-8249
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๐ SIMILAR VOLUMES
field desorption mass spectrum (m/e= 206 for CpV(NO):)[41; in nitromethane solution it behaves as a 1 : 1 electrolyte. The pronounced electron deficit at the central metal of ( I ) is reflected in the high v(N0) frequencies in the IR spectrum and in the strong deshielding of the cyclopentadienyl pro
A procedure for the solid-phase synthesis of oligourea acids with UV irradiation when a photocleavable linker is used or as C-terminal hydantoins with 10% TEA/MeOH and peptidomimetics starting from Boc-protected monomers is described. The compounds are prepared on Tentagel ยฎ resin a catalytic amount