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Asymmetric reduction of ketoxime O-alkyl ethers with chirally modified NaBH4?ZrCl4
β Scribed by Itsuno, Shinichi; Sakurai, Yoshiki; Shimizu, Koji; Ito, Koichi
- Book ID
- 118043902
- Publisher
- Royal Society of Chemistry
- Year
- 1990
- Weight
- 549 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1472-7781
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π SIMILAR VOLUMES
The asymmetric reduction of ketoxime ethers to yield enantiomerically enriched chiral hydroxylamines with reagents prepared from borane and norephedrine has been investigated. Very high enantioselectivity (ca. 99% ee) was obtained in the reduction of ketoxime O-(o-nitrobenzyl) ether to O-(o-nitroben
Asymmetric Reduction of Ketoxime Ethers to Optically Active O-Substituted Hydroxylamines with Reagents Prepared from Borane and Chiral Amino Alcohols. -The reduction in the presence of norephedrine is an efficient method to prepare chiral O-substituted hydroxylamines. However, O-Tbs and O-tBu subst