Asymmetric synthesis using chirally modified borohydrides. Part 3. Enantioselective reduction of ketones and oxime ethers with reagents prepared from borane and chiral amino alcohols
โ Scribed by Itsuno, Shinichi; Nakano, Michio; Miyazaki, Koji; Masuda, Hirofumi; Ito, Koichi; Hirao, Akira; Nakahama, Seiichi
- Book ID
- 118233338
- Publisher
- Royal Society of Chemistry
- Year
- 1985
- Weight
- 815 KB
- Category
- Article
- ISSN
- 1472-7781
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๐ SIMILAR VOLUMES
The asymmetric reduction of ketoxime ethers to yield enantiomerically enriched chiral hydroxylamines with reagents prepared from borane and norephedrine has been investigated. Very high enantioselectivity (ca. 99% ee) was obtained in the reduction of ketoxime O-(o-nitrobenzyl) ether to O-(o-nitroben
Asymmetric Reduction of Ketoxime Ethers to Optically Active O-Substituted Hydroxylamines with Reagents Prepared from Borane and Chiral Amino Alcohols. -The reduction in the presence of norephedrine is an efficient method to prepare chiral O-substituted hydroxylamines. However, O-Tbs and O-tBu subst