Asymmetric reduction of ketones with crystalline cyclodextrin complexes of amine-boranes
β Scribed by Sakuraba, Hidetake; Inomata, Naruto; Tanaka, Yoshio
- Book ID
- 126954835
- Publisher
- American Chemical Society
- Year
- 1989
- Tongue
- English
- Weight
- 462 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
Ammonia borane and primary amine boranes are highly chemoselective reducing agents for aldehydes and ketones. There has been much recent interest in the development of chemoselective1s2 reducing agents capable of distinguishing aldehyde and ketone functionality in a predictable manner. 'a-si While a
## Abstract The enantioselective reduction of ketones was accomplished by borane in the presence of pyrazole derivatives, particularly 2βmethoxymethylβ3βphenylβ1βmenthopyrazole (8). The catalysis of zinc chloride makes it possible to lower the reaction temperature below 0 Β°C, and to promote enantio