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Reduction of Steroidal Ketones with Amine—Boranes.

✍ Scribed by A. E. Leontjev; L. L. Vasiljeva; K. K. Pivnitsky


Publisher
John Wiley and Sons
Year
2005
Weight
24 KB
Volume
36
Category
Article
ISSN
0931-7597

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Borane Reduction of the Steroid 20-Keton
✍ Göndös, György ;Orr, James C. 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 173 KB

## Abstract The direction of reduction of 20‐carbonyl group of 3α‐hydroxy‐5β‐pregnan‐20‐one (1) with a complex of borane‐methyl sulfide and chiral β‐amino alcohols, depends on the chirality of the amino alcohol. Where there is a 2‐phenyl or 2‐benzyl substituent, then the __S__ enantiomer gives excl