Asymmetric reduction of aromatic ketones with borane-amine complexes modified with optically pure 2,2′-dihydroxy-6,6′-dimethylbiphenyl
✍ Scribed by Hiroshi Suda; Shigeyoshi Kanoh; Nobuhiro Umeda; Takashi Nakajo; Masatoshi Motoi
- Book ID
- 104217146
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- French
- Weight
- 258 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0040-4039
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Reductions performed with Ti(IV) complexes of ligands based on bicyclo[2.2.2]octane diols 5 and 6 are effective catalysts in the reduction of prochiral ketones to optically active alcohols, with catecholborane as the reducing agent. Methyl ketones are favored and enantiomeric excesses (ee) of < or =
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