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Asymmetric Reduction of 2-Chloro-3-oxo Esters by Transfer Hydrogenation

✍ Scribed by Jinjin Bai; Shifeng Miao; Yun Wu; Yawen Zhang

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 99 KB
Volume: 29
Category: Article
ISSN: 0256-7660
DOI: 10.1002/cjoc.201180419

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✦ Synopsis

Abstract

Asymmetric reduction of 2‐chloro‐3‐oxo esters was achieved by catalytic transfer hydrogenation using RuCl~2~(p‐cymene)‐TsDPEN as the chiral catalyst and HCOOH‐Et~3~N as the hydrogen source. Moderate to good yields (up to 85%) and good enantioselectivities (up to 98% ee) were obtained.

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