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Asymmetric Induction Effects in the Preparation of Penicillin-Analogous Thiazepines

✍ Scribed by Klar, Bernhard ;Imming, Peter

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
828 KB
Volume
1997
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

N‐Acyldehydroalanines 3 react with cysteine and penicillamine esters to give a single diastereomer of the thiazepines 6. By modifying this reaction, the requirements for steric control were elucidated and a series of penicillin analogs 6 and 12 prepared.

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