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Asymmetric Hydrogenation of Quinoxalines with Diphosphinite Ligands: A Practical Synthesis of Enantioenriched, Substituted Tetrahydroquinoxalines

✍ Scribed by Weijun Tang; Lijin Xu; Qing-Hua Fan; Jun Wang; Baomin Fan; Zhongyuan Zhou; Kim-hung Lam; Albert S. C. Chan


Book ID
101569706
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
288 KB
Volume
48
Category
Article
ISSN
0044-8249

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## Abstract A highly efficient and general iridium‐difluorphos‐catalyzed asymmetric hydrogenation of diverse 2‐alkyl‐ and 2‐aryl‐substituted quinoxalines into biologically and pharmaceutically relevant 2‐substituted‐1,2,3,4‐tetrahydroquinoxaline units has been developed. High isolated yields and ex