✦ LIBER ✦
Iridium-Difluorphos-Catalyzed Asymmetric Hydrogenation of 2-Alkyl- and 2-Aryl-Substituted Quinoxalines: A General and Efficient Route into Tetrahydroquinoxalines
✍ Scribed by Damien Cartigny; Takuto Nagano; Tahar Ayad; Jean-Pierre Genêt; Takashi Ohshima; Kazushi Mashima; Virginie Ratovelomanana-Vidal
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 175 KB
- Volume
- 352
- Category
- Article
- ISSN
- 1615-4150
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✦ Synopsis
Abstract
A highly efficient and general iridium‐difluorphos‐catalyzed asymmetric hydrogenation of diverse 2‐alkyl‐ and 2‐aryl‐substituted quinoxalines into biologically and pharmaceutically relevant 2‐substituted‐1,2,3,4‐tetrahydroquinoxaline units has been developed. High isolated yields and excellent enantioselectivities of up to 95% for 2‐alkyl‐substituted quinoxalines and of up to 94% for 2‐aryl‐substituted quinoxalines were obtained.