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Asymmetric Catalysis of the Strecker Amino Acid Synthesis by a Cyclic Dipeptide

โœ Scribed by Iyer, Mani S.; Gigstad, Kenneth M.; Namdev, Nivedita D.; Lipton, Mark


Book ID
120210129
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
82 KB
Volume
118
Category
Article
ISSN
0002-7863

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A series of cycZo(Aaminoacyl-L-Ala) (fl) (A=a,@dehydro) were prepared from cycZo(Gly-L-Ala) and corresponding aldehyde, and hydrogenated with Pd black in MeOH. Chiral inductions producing CycZo(L-aminoacyl-L-Ala) (2) from 2 were 96-99% in the case of L-Aba (2-eminobutanoic acid), L-Val, L-Leu, and L