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Asymmetric Bioreductions of β-Nitro Acrylates as a Route to Chiral β 2 -Amino Acids

✍ Scribed by Swiderska, Magdalena A.; Stewart, Jon D.


Book ID
126173018
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
59 KB
Volume
8
Category
Article
ISSN
1523-7060

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✍ Ian T. Barnish; Martin Corless; Peter J. Dunn; David Ellis; Paul.W. Finn; J.Davi 📂 Article 📅 1993 🏛 Elsevier Science 🌐 French ⚖ 254 KB

The addition of lithium enolates to chiral aminomethylacrylates 7 and 8 proceeded with excellent diastereodifferentiation (up to 98% de) and provided an expeditious synthesis of homochiral fi-aminomethylglutarates 9 and 10, on a scale of up-to 5OOg. The a&lates 7 and%, and their antipodes, should be