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Asymmetric alkylation and sulphenylation of chiral O-silylated imide enolates.

โœ Scribed by Rikki P. Alexander; Ian Paterson


Book ID
104226917
Publisher
Elsevier Science
Year
1985
Tongue
French
Weight
136 KB
Volume
26
Category
Article
ISSN
0040-4039

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O-Silylated ketone enolates can be alkylated regiospecifically with t-alkyl halides in the presence of an equivalent of titanium tetrachloride; 2 for the alkylation of lithium enolates, in general, dialkylation,3 loss of regiospecificity,3 and self-condensation4 are common problems. Alternative me