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Asymmetric Agonist Selectivity of Agonist Sites in (α4β2)2α4 Nicotinic Acetylcholine Receptors: A Key Determinant of Agonist Efficacy

✍ Scribed by Mazzaferro, Simone; Gasparri, federica; New, Karina; Alcaino, Constanza; Bermudez, Isabel

Book ID: 122911941
Publisher: Biophysical Society
Year: 2014
Tongue: English
Weight: 46 KB
Volume: 106
Category: Article
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2013.11.1937

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## Abstract An efficient synthesis of (1__R__,5__S__)-6-(5-cyano-3-pyridinyl)-3,6-diaza-bicyclo[3.2.0]heptane **A-366833**, a novel potent selective neuronal nicotinic receptor (NNR) agonist, is described. The enantiomerically pure pharmacophore benzyl (1__S__,5__S__)-3,6-diaza-bicyclo[3.2.0]heptan