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Isoanatabine, a naturally occurring α4β2 nicotinic receptor agonist

✍ Scribed by H. Xing; A. Rouchaud; S. Keshwah; W.R. Kem

Book ID
113488898
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
99 KB
Volume
78
Category
Article
ISSN
0006-2952

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✍ John A. Lowe III; Shari L. DeNinno; Jotham W. Coe; Lei Zhang; Scot Mente; Raymon 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 243 KB

We report the synthesis of a series of [3.2.1]azabicyclic biaryl ethers as selective agonists of a3and a6-containing nicotinic receptors. In particular, compound 17a from this series is a potent a3b4 and a6/4b4 receptor agonist in terms of both binding and functional activity. Compound 17a also show