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Synthesis, Pharmacology, and Biostructural Characterization of Novel α 4 β 2 Nicotinic Acetylcholine Receptor Agonists

✍ Scribed by Ussing, Christine A.; Hansen, Camilla P.; Petersen, Jette G.; Jensen, Anders A.; Rohde, Line A. H.; Ahring, Philip K.; Nielsen, Elsebet Ø.; Kastrup, Jette S.; Gajhede, Michael; Frølund, Bente; Balle, Thomas

Book ID
118278922
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
529 KB
Volume
56
Category
Article
ISSN
0022-2623

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✍ Dr. Clelia Dallanoce; Dr. Pietro Magrone; Dr. Carlo Matera; Dr. Fabio Frigerio; 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 640 KB

## Abstract A set of racemic spirocyclic quinuclidinyl‐Δ^2^‐isoxazoline derivatives was synthesized using a 1,3‐dipolar cycloaddition‐based approach. Target compounds were assayed for binding affinity toward rat neuronal homomeric (α7) and heteromeric (α4β2) nicotinic acetylcholine receptors. Δ^2^‐