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Synthesis and Structure−Activity Relationship Studies of 3,6-Diazabicyclo[3.2.0]heptanes as Novel α4β2 Nicotinic Acetylcholine Receptor Selective Agonists

✍ Scribed by Sippy, Kevin B.; Bunnelle, William H.; Li, Tao; Anderson, David J.; Faltynek, Connie; Surowy, Carol S.; Dyhring, Tino; Ahring, Philip K.; Ji, Jianguo; Schrimpf, Michael R.


Book ID
111690970
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
283 KB
Volume
50
Category
Article
ISSN
0022-2623

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A novel series of [3.2.1] azabicyclic bi
✍ John A. Lowe III; Shari L. DeNinno; Jotham W. Coe; Lei Zhang; Scot Mente; Raymon 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 243 KB

We report the synthesis of a series of [3.2.1]azabicyclic biaryl ethers as selective agonists of a3and a6-containing nicotinic receptors. In particular, compound 17a from this series is a potent a3b4 and a6/4b4 receptor agonist in terms of both binding and functional activity. Compound 17a also show