Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT)
β Scribed by Rees, M; Norton, N; Jones, I; McCandless, F; Scourfield, J; Holmans, P; Moorhead, S; Feldman, E; Sadler, S; Cole, T
- Book ID
- 110058785
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 67 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1359-4184
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A variable number tandem repeat (VNTR) polymorphism consisting of multiple copies of a 17-bp repeat in the second intron of the serotonin transporter gene (SERT) has been reported. Different alleles of this VNTR have been found to be associated with bipolar disorder and schizophrenia. These findings
It has been suggested that the serotonin transporter (5-hydroxytryptamine-transporter or 5-HTT) may be involved in the pathogenesis of affective disorders. Recently, Collier et al. (1996) found that the frequency of the low-activity short variant (s) of the 5-HTT-linked polymorphic region (5-HTTLPR)