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Multimarkerhaplotypes within the serotonin transporter gene suggest evidence of an association with bipolar disorder

✍ Scribed by Mynett-Johnson, L. ;Kealey, C. ;Claffey, E. ;Curtis, D. ;Bouchier-Hayes, L. ;Powell, C. ;McKeon, P.


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
89 KB
Volume
96
Category
Article
ISSN
0148-7299

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Analysis of a novel functional polymorph
✍ de Oliveira, JoοΏ½o R. Mendes; Otto, Paulo A.; Vallada, Homero; Lauriano, ValοΏ½ria; πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 11 KB πŸ‘ 2 views

It has been suggested that the serotonin transporter (5-hydroxytryptamine-transporter or 5-HTT) may be involved in the pathogenesis of affective disorders. Recently, Collier et al. (1996) found that the frequency of the low-activity short variant (s) of the 5-HTT-linked polymorphic region (5-HTTLPR)

No association of an insertion/deletion
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A recent Japanese study on the angiotensin I converting enzyme gene (ACE) insertion/ deletion polymorphism reported that both the D allele (P < 0.02) and the DD genotype (P < 0.002) were significantly more frequent in affective disorder cases than in controls [Arinami et al., 1996: Biol Psychiatry 4