## Abstract The pathophysiological mechanisms underlying binge eating disorder (BED) are poorly understood. There is evidence that abnormalities in brain serotonin (5HT) play an important role in binge eating behavior, therefore genes involved in 5HT transmission, such as the 5HT transporter (5HTT)
Association study of a novel functional polymorphism of the serotonin transporter gene in bipolar disorder and suicidal behaviour
β Scribed by Vincenzo De Luca; Subi Tharmalingam; Nicole King; John Strauss; Natalie Bulgin; James L. Kennedy
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 75 KB
- Volume
- 182
- Category
- Article
- ISSN
- 0033-3158
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There is evidence indicating that density of 5-HT2A receptors is altered in brain regions of depressed suicide victims and in platelets of suicidal subjects with major depression or schizophrenia. Recent studies have also shown an association between the allele C of 102T/C polymorphism in the 5-HT2A
It has been suggested that the serotonin transporter (5-hydroxytryptamine-transporter or 5-HTT) may be involved in the pathogenesis of affective disorders. Recently, Collier et al. (1996) found that the frequency of the low-activity short variant (s) of the 5-HTT-linked polymorphic region (5-HTTLPR)