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Association ofp53codon 72 genetic polymorphism with the risk of ulcerative colitis in northern Iran

✍ Scribed by Salaheddin Vaji; Zivar Salehi; Keyvan Aminian


Publisher
Springer
Year
2010
Tongue
English
Weight
131 KB
Volume
26
Category
Article
ISSN
0179-1958

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A single nucleotide polymorphism (SNP) in the promoter of MDM2 gene, SNP309 T>G (a T-G exchange at nucleotide 309 in the first intron), can increase the expression level of MDM2, thereby causing an impairment of p53 tumor suppressor activity. A G-C exchange at p53 codon 72 polymorphism results in a