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Association of the Tau haplotype with Parkinson's disease in the Greek population

✍ Scribed by Liana Fidani; Kallirhoe Kalinderi; Sevasti Bostantjopoulou; Jordi Clarimon; Antonis Goulas; Zoe Katsarou; John Hardy; Alexandros Kotsis

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
59 KB
Volume
21
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

We compared the distribution of the Tau H1 haplotype and related subhaplotypes in a group of clinically diagnosed Parkinson's disease patients (n = 133) and in control individuals (n = 113) from northern Greece. We were able to detect a statistically significant overrepresentation of the H1H1 genotype in our patient group (OR for H1H1 vs. H1H2 and H2H2: 1.73; 95% CI: 1.03–2.90; P = 0.037). The H1 subhaplotype significantly associated with the disease in our population was different from the one previously reported for a Norwegian population, suggesting that the nature of the association of Tau with Parkinson's disease is influenced by ethnic variation. Β© 2006 Movement Disorder Society

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