## Abstract The presynaptic dopamine transporter in nigral dopaminergic neurons confers susceptibility to the cytotoxic effects of the neurotoxic metabolite of 1βmethy1β4βphenylβ1,2,3,6βtetrahydropyridine. Polymorphisms in the dopamine transporter might influence the susceptibility to such toxins.
Lack of association of the UCHL-1 gene with Parkinson's disease in a greek cohort: A haplotype-tagging approach
β Scribed by Georgia Xiromerisiou; Elli Kyratzi; Efthimios Dardiotis; Maria Bozi; Vana Tsimourtou; Eleftherios Stamboulis; Styliani Ralli; Demetrios Vassilatis; Vanessa Gourbali; Persa-Maria Kountra; Kostas Fountas; Alexandros Papadimitriou; Leonidas Stefanis; Georgios M. Hadjigeorgiou
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 573 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0885-3185
No coin nor oath required. For personal study only.
β¦ Synopsis
The disorders of voice and speech in Parkinson's disease (PD) result from involvements in several subsystems including respiration, phonation, articulation, and prosody. [1][2][3] We investigated the feasibility of acoustic measures for the identification of voice and speech disorders in PD, using a quick vocal test consisting of sustained phonation, diadochokinetic task, and running speech. Various traditional and novel acoustic measurements have been designed in order to be gender independent, represent all speech subsystems, reduce the time required for voice investigation, and provide a reliable automated assessment in practice. 4
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## 817 ated with increased risk for AD, at least in the Korean population. Nevertheless, it cannot be excluded that the association between IL-1A (-889) C/T polymorphism and AD observed in previous studies might be the result of linkage disequilibrium with a yet unidentified gene on chromosome 2.