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Association of t(15;17) and t(8;21) in the initial phase of an acute promyelocytic leukemia

✍ Scribed by Christiane Charrin; Danièle Ritouet; Lydia Campos; Yves Devaux; Eric Archimbaud; Jacqueline Fraisse; Denis Fiere; Daniel Germain

Book ID: 119105364
Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 716 KB
Volume: 58
Category: Article
ISSN: 0165-4608
DOI: 10.1016/0165-4608(92)90108-k

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## Abstract The genomic breakpoints in the t(15;17)(q22;q21), associated with acute promyelocytic leukemia (APL), are known to occur within three different __PML__ breakpoint cluster regions (bcr) on chromosome 15 and within __RARA__ intron 2 on chromosome 17; however, the precise mechanism by whic