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110. Molecular genetics of the t(15;17) of acute promyelocytic leukemias (APL)

✍ Scribed by Grignani, Fr; Pandolfi, PP; Alcalay, M; Fagioli, M; Mencarelli, A; Grignani, F; Pelicci, PG

Book ID
122984261
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
95 KB
Volume
46
Category
Article
ISSN
0753-3322

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The chromosome breakpoints of the acute promyelocytic leukemia (APL)-specific 15;17 translocation have recently been isolated. They are localized on a previously unknown gene, PML, on chromosome 15 and in the gene that encodes the alpha retinoic acid receptor (RART) on 17. The translocation, which i

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## Abstract The genomic breakpoints in the t(15;17)(q22;q21), associated with acute promyelocytic leukemia (APL), are known to occur within three different __PML__ breakpoint cluster regions (bcr) on chromosome 15 and within __RARA__ intron 2 on chromosome 17; however, the precise mechanism by whic