Co-expression of two FAB-specific chromosome changes, t(15; 17) and t(8; 21), in a case of acute promyelocytic leukemia

Analysis of t(15;17) chromosomal breakpo

Analysis of t(15;17) chromosomal breakpoint sequences in therapy-related versus de novo acute promyelocytic leukemia: Association of DNA breaks with specific DNA motifs at PML and RARA loci

✍ Syed Khizer Hasan; Tiziana Ottone; Richard F. Schlenk; Yuanyuan Xiao; Joseph L. 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 552 KB

## Abstract We compared genomic breakpoints at the __PML__ and __RARA__ loci in 23 patients with therapy‐related acute promyelocytic leukemia (t‐APL) and 25 de novo APL cases.Eighteen of 23 t‐APL cases received the topoisomerase II poison mitoxantrone for their primary disorder. DNA breaks were clu