## Abstract ## Objective The HLA shared epitope (SE) alleles are primarily a risk factor for the presence of antibodies to cyclic citrullinated peptide (anti‐CCP antibodies) rather than for the development of rheumatoid arthritis (RA). The SE alleles interact with the environmental risk factor tob
Association of smoking with the constitution of the anti–cyclic citrullinated peptide response in the absence of HLA–DRB1 shared epitope alleles
✍ Scribed by K. N. Verpoort; E. A. M. Papendrecht-van der Voort; A. H. M. van der Helm-van Mil; C. M. Jol-van der Zijde; M. J. D. van Tol; J. W. Drijfhout; F. C. Breedveld; R. R. P. de Vries; T. W. J. Huizinga; R. E. M. Toes
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 116 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract ## Objective To examine the association between HLA–DRB1 alleles and the production of anti–cyclic citrullinated peptide (anti‐CCP) and rheumatoid factor (RF) autoantibodies in patients with rheumatoid arthritis (RA). ## Methods We studied 1,723 Caucasian RA patients enrolled in the
## Abstract ## Objective The shared epitope (SE)–containing HLA–DRB1 alleles represent the most significant genetic risk factor for rheumatoid arthritis (RA). Recent studies indicate that the SE alleles are associated with only RA that is characterized by the presence of anti–cyclic citrullinated