Association of peptide chains during Merrifield solid-phase peptide synthesis. A deuterium NMR study
β Scribed by Ludwick, Adriane G.; Jelinski, Lynn W.; Live, David.; Kintanar, Agustin.; Dumais, Joseph J.
- Book ID
- 126434541
- Publisher
- American Chemical Society
- Year
- 1986
- Tongue
- English
- Weight
- 498 KB
- Volume
- 108
- Category
- Article
- ISSN
- 0002-7863
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π SIMILAR VOLUMES
Three short peptides were synthesized on Merrifield resin (PS-DVB) and on polystyrene crosslinked with 1,6-hexanediol diacrylate resin (PS-HDODA) to compare their efficiencies in solid-phase peptide synthesis (SPPS). A 2% crosslinked polymeric system having almost equal capacity was used in both cas
## Abstract An improved method for the preparation of Merrifield resin esters is presented. This method is rapid, is free of racemization, and is not complicated by a quaternization side reaction. Chloromethylated resin beads, __t__βbutoxycarbonyl amino acid, and potassium __t__βbutoxide are heated