Association of IL-1 polymorphisms and IL-1 serum levels with susceptibility to nasopharyngeal carcinoma

✍ Scribed by Zhi-Hui Yang; Qiong Dai; Li Zhong; Xu Zhang; Qing-Xi Guo; Shi-Ning Li

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 103 KB
• Volume: 50
• Category: Article
• ISSN: 0899-1987
• DOI: 10.1002/mc.20706

✦ Synopsis

Abstract

Previous studies demonstrated that the polymorphism of interleukin‐1 (IL‐1) produce alterations of the protein expression and may contribute to oncogenetic processes. The aim of this study was to investigate the relationship between IL‐1A gene polymorphisms and NPC susceptibility and the influence of on IL‐1α serum levels in cases versus controls. To test whether the genetic variants of IL‐1A gene modify the risk of nasopharyngeal carcinoma (NPC), we compared the −889C/T and rs3783553 polymorphisms between 248 patients with NPC and 296 healthy controls using polymerase chain reaction–restriction fragment length polymorphism. Serum IL‐1α levels were measured by enzyme‐linked immunosorbent assay. The rs3783553 (TTCA insertion or deletion) polymorphism of the IL‐1A gene was significantly associated with the susceptibility to NPC. The variant homozygote genotype +/+ was associated with a significantly reduced risk of NPC as compared with the wild homozygote −/− genotype, and the serum IL‐1α levels were significantly lower in individuals with homozygous +/+ genotypes. No association was found between the −889C/T polymorphisms and risk of NPC, and no statistically significant differences were found between rs3783553 polymorphism and clinical pathology indices. The IL‐1A rs3783553 polymorphism might contribute to a risk of developing NPC by affecting the serum IL‐1α secretion in the Chinese population. Mol. Carcinog. © 2010 Wiley‐Liss, Inc.