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Association of IL-1Ra gene polymorphism, but no association of IL-1β and IL-4 gene polymorphisms, with Kawasaki disease

✍ Scribed by Shu-Fen Wu; Jeng-Sheng Chang; Lei Wan; Chang-Hai Tsai; Fuu-Jen Tsai

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
85 KB
Volume
19
Category
Article
ISSN
0887-8013

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✦ Synopsis

Abstract

The purpose of this study was to evaluate whether IL‐1 β (IL‐1β promoter and IL‐1β exon 5), IL‐1 receptor antagonist (IL‐1 Ra), and IL‐4 (IL‐4 promoter and IL‐4 intron 3) gene polymorphisms act as markers of susceptibility to Kawasaki disease (KD), or of the severity of the disease. The study included 107 KD patients and 103 normal controls. Polymorphisms for cytokine genes were detected by polymerase chain reaction (PCR). Genotypes and allelic frequencies for cytokine gene polymorphisms in both groups were compared. No significant difference was observed in the genotypes and allelic frequencies of cytokines between patients with coronary aneurysm and without. In addition, there was no significant association in the genotype and allelic frequencies of IL‐1 beta, IL‐4, and IL‐6 in patients with KD. The genotype I/II for IL1‐Ra and the frequency of allele II for IL1‐Ra are associated with a higher susceptibility to KD, and thus may be useful markers for predicting the development of KD. J. Clin. Lab. Anal. 19:99–102, 2005. © 2005 Wiley‐Liss, Inc.

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