Association of cold-reactive antilymphocyte antibodies with lymphopenia in systemic lupus erythematosus
β Scribed by John B. Winfield; Robert J. Winchester; Henry G. Kunkel
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- English
- Weight
- 618 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0004-3591
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## Abstract Antilymphocyte antibodies in serum from patients with systemic lupus erythematosus (SLE), as detected by microcytotoxicity and indirect immunofluorescence, were predominantly cold reactive and of the IgM class. These IgM antibodies were most active at 4Β°C. IgG antibodies were infrequent
In previous studies, we demonstrated that patients with active systemic lupus erythematosus (SLE) had significantly decreased percentages of circulating CD4+ 2H4+ suppressorlinducer cells. The decrease in this T cell subset was most frequent and most marked in patients with active SLE and renal dise