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Association of cold-reactive antilymphocyte antibodies with lymphopenia in systemic lupus erythematosus

✍ Scribed by John B. Winfield; Robert J. Winchester; Henry G. Kunkel


Publisher
John Wiley and Sons
Year
1975
Tongue
English
Weight
618 KB
Volume
18
Category
Article
ISSN
0004-3591

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πŸ“œ SIMILAR VOLUMES


Nature of cold-reactive antibodies to ly
✍ Dr John B. Winfield; Robert J. Winchester; Peter Wernet; Shu Man Fu; Henry G. Ku πŸ“‚ Article πŸ“… 1975 πŸ› John Wiley and Sons 🌐 English βš– 929 KB

## Abstract Antilymphocyte antibodies in serum from patients with systemic lupus erythematosus (SLE), as detected by microcytotoxicity and indirect immunofluorescence, were predominantly cold reactive and of the IgM class. These IgM antibodies were most active at 4Β°C. IgG antibodies were infrequent

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In previous studies, we demonstrated that patients with active systemic lupus erythematosus (SLE) had significantly decreased percentages of circulating CD4+ 2H4+ suppressorlinducer cells. The decrease in this T cell subset was most frequent and most marked in patients with active SLE and renal dise