Cross-reactivity of antiidiotypic antibodies with DNA in systemic lupus erythematosus
β Scribed by Elvira R. Eivazova; James M. McDonnell; Brian J. Sutton; Norman A. Staines
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 574 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0004-3591
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π SIMILAR VOLUMES
## Abstract Twentyβone sera from 11 patients with systemic lupus erythematosus were titrated with ^125^Iβssβcalf thymus DNA to determine their maximum capacity to bind DNA. Only five sera were capable of binding > 90% of the input DNA. The remaining sixteen sera showed maximum DNA binding levels be
Sera obtained from fifty-five patients with active systemic lupus erythematosus (SLE) and from four patients with mixed connective tissue disease (MCTD) previously shown by immunofluorescence and by double immunodiffusion to possess antinuclear antibodies, were tested for the presence of natural ant