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Surface antigen specificity of cold-reactive IgM antilymphocyte antibodies in systemic lupus erythematosus

โœ Scribed by Akira Yamada; Melody Shaw; John B. Winfield

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
777 KB
Volume
28
Category
Article
ISSN
0004-3591

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## Abstract Antilymphocyte antibodies in serum from patients with systemic lupus erythematosus (SLE), as detected by microcytotoxicity and indirect immunofluorescence, were predominantly cold reactive and of the IgM class. These IgM antibodies were most active at 4ยฐC. IgG antibodies were infrequent

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Antibody a c t i v i t y t o various histones was examined i n a s o l i d phase radioimmunoassay. More than one h a l f o f the sera from systemic lupus erythematosus (SLE) p a t i e n t s had IgM a c t i v i t y t o t o t a l histones, and a s l i g h t l y lower frequency was observed f o r IgG a