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Association of cholecystokinin-a receptor gene polymorphisms and panic disorder in japanese

✍ Scribed by Miyasaka, Kyoko; Yoshida, Yuki; Ohta, Minoru; Kanai, Setsuko; Hosoya, Hiroko; Yamakawa, Naomi; Shirakawa, Osamu; Matsushita, Sachio; Higuchi, Susumu; Funakoshi, Akihiro

Book ID: 121940869
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 174 KB
Volume: 124
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(03)81512-3

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Cholecystokinin (CCK) is one of the most abundant neurotransmitter peptides in the brain. CCK appears to play an important role in the neurobiology of anxiety and panic disorders (PD) in both humans and animals. Recently, we reported that lack of CCKAR had a significant anxiogenic-like effect in rat