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Association between TP53 Arg72Pro polymorphism and thyroid carcinoma risk

✍ Scribed by Wang, Fang; Wang, Peng; Wang, Bin; Fu, Zheng-Ju; Yuan, Ying; Yan, Sheng-Li; Zhao, Wen-Juan; Wang, Yan-Gang

Book ID: 125384018
Publisher: S. Karger AG
Year: 2013
Tongue: English
Weight: 228 KB
Volume: 35
Category: Article
ISSN: 1010-4283
DOI: 10.1007/s13277-013-1359-x

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## Abstract It is well known that the TP53 gene considerably influences on DNA repair processes. Polymorphisms in the TP53 gene, particularly the well‐known Arg72Pro in codon 72 of exon 4 (Ex4+119 G>C; rs1042522), can modify the functionality of the p53 protein and activation of DNA repair. Actuall