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Association between restriction fragment length polymorphism of the L-myc gene and lung metastasis in human breast cancer

✍ Scribed by Marie-Hélène Champeme; Ivan Bieciie; Alain Latil; Kamel Hacene; Rosette Lidereau

Publisher
John Wiley and Sons
Year
1992
Tongue
French
Weight
528 KB
Volume
50
Category
Article
ISSN
0020-7136

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✦ Synopsis

EcoRl restriction fragment length polymorphism (RFLP) of the L-rnyc gene was examined in leukocyte DNAs isolated from 381 breast cancer patients. No differences in the patterns of L-rnyc RFLP were found between breast cancer patients and healthy individuals. However, among 97 patients who relapsed, a statistical correlation was found between L-rnyc RFLP and lung metastases (p < 0.05). These results are in close agreement with previous findings in patients with cancer of the lung, bone or kidney, and suggest that L-myc RFLP may be a useful marker for predicting lung metastasis in some human cancers.

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