Association between rb-1 gene alterations and factors of favourable prognosis in human breast cancer, without effect on survival
✍ Scribed by Els M. J. J. Berns; Annelies De Klein; Wim L. J. Van Putten; Iris L. Van Staveren; Aart Bootsma; Jan G. M. Klijn; John A. Foekens
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- French
- Weight
- 783 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
The retinoblastoma (RB) tumour suppressor gene has been associated not only with retinoblastoma but also with several other tumours like osteosarcoma, small cell lung carcinoma and prostate and breast cancer. We have studied the incidence of RB gene alterations in 96 primary breast turnours using Southern blotting techniques. The outcome has been related with patient and tumour characteristics, oncogene amplifications, p53 mutations and prognosis. RB gene alterations were found to occur more frequently in estrogen receptor (ER)-positive than in ER-negative tumours and less frequently in tumours with oncogene amplification than in tumours without oncogene amplification of HERZ/neu, c-rnyc or I I q 13. RB gene alteration was observed in tumours both with and without a p53 gene mutation. Data on 87 patients (mean age, 59.6 years; median follow-up, 108 months) and RB gene alterations revealed a significant association between the frequency of RB gene alterations and node-negative patients (p < 0.01) or smaller (<2