Restriction fragment length polymorphism analysis of the l-myc gene locus in a case-control study of lung cancer

✍ Scribed by Seiichi Tamai; Haruhiko Sugimura; Neil E. Caporaso; James H. Resau; Benjamin F. Trump; Ainsley Weston; Curtis C. Harris

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: French
• Weight: 614 KB
• Volume: 46
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910460314

✦ Synopsis

Abstract

The L‐myc DNA‐restriction fragment length polymorphism, revealed by __Eco__RI, has been studied in both a lung cancer case‐control framework and a cohort of 40 nondiseased unrelated individuals. No association was found between the L‐myc allelic frequencies and disease status, tumor stage or lung cancer histology. A strong association was, however, observed between the L‐myc allelic frequencies and ethnic origin (black or white) of the subjects. Among American whites the allelic distribution at the L‐myc proto‐oncogene locus was almost identical to that previously reported for Japanese subjects. Among the American black population there was a significantly higher frequency of the presence of the polymorphic __Eco__RI restriction site in the second intron of the L‐myc proto‐oncogene. These data emphasize the importance of conducting epidemiologic studies that control for ethnic factors and indicate that L‐__myc Eco__RI allelotypes do not appear to be predictive of lung cancer risk or disease status in American blacks and whites.